JNJ-40418677

MedChem Express

JNJ-40418677 [1146594-87-7]

10

1146594-87-7

99.0

C26H22F6O2

480.44

JNJ-40418677 is an orally active modulator of gamma-secretase , can cross the blood-brain barrier. JNJ-40418677 inhibits Abeta42 and NS2B-NS3 protease , with IC 50 s of 200 nM and 3.9 microM, respectively. JNJ-40418677 displays good biological tolerance, can be use for Alzheimers disease research [1] [2] [3] .

CC(C)C[C@@H](C1=CC(C2=CC=C(C=C2)C(F)(F)F)=CC(C3=CC=C(C=C3)C(F)(F)F)=C1)C(O)=O

-20°C

12352200