JNK (phospho Tyr185) antibody [EP1597Y]

GeneTex

JNK (phospho Tyr185) antibody [EP1597Y]

9

This antibody is raised against JNK1/2 phosphorylated at Tyr185. Based on sequence homology, it is predicted to react with JNK3 when phosphorylated at the corresponding residues - Tyr223.

ImmunoPrecipitation, Western Blot

Research Use Only

Monoclonal

EP1597Y

Unconjugated

MAPK8

mitogen-activated protein kinase 8

c-Jun N-terminal kinase 1; JNK; JNK1; JNK1A2; JNK21B1/2; JNK-46; JUN N-terminal kinase; MAP kinase 8; mitogen-activated protein kinase 8; PRKM8; SAPK1; SAPK1c; stress-activated protein kinase 1; stress-activated protein kinase 1c

Rabbit

IgG

Phosphorylated

C-Jun N-terminal kinases (JNK) are distantly related to mitogen-activated protein kinases (ERKs) and are activated by dual phosphorylation on Tyr and Thr. The JNK protein kinase group consists of three isoforms (JNK1, 2, and 3) and regulates transcription activity of the AP-1 complex, and release and regulation of cytochome c . JNK becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase MKK4 and MKK7 . Unlike other JNK isoforms, JNK3 is only expressed in the heart and nervous system. JNK3 has been implicated in stress-induced neuronal apoptosis .

Human, Mouse, Rat

2°C to 8°C,-20°C or -80°C

12352203