JNK1 Polyclonal Antibody

Reddot Biotech

JNK1 Polyclonal Antibody

5

ImmunoHistoChemistry

Research Use Only

Polyclonal

2 mg/ml

Unconjugated

Mapk8

mitogen-activated protein kinase 8

c-jun NH2-terminal kinase; c-Jun N-terminal kinase 1; JNK; MAP kinase 8; MAPK 8; mitogen-activated protein kinase 8; p54 gamma; SAPK gamma; stress-activated protein kinase JNK1

Rabbit

IgG

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

Rat

-20°C

12352203