Immunohistochemistry analysis of paraffin-embedded Mouse lung using JNK1/2/3 Polyclonal Antibody at dilution of 1:200.
Immunohistochemistry analysis of paraffin-embedded Mouse lung using JNK1/2/3 Polyclonal Antibody at dilution of 1:200.
JNK1/2/3 Polyclonal Antibody
E-AB-70345
Product group Antibodies
Overview
- SupplierElabscience
- Product NameJNK1/2/3 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific Descriptionc-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield ten isoforms through alternative mRNA splicing, including JNK1alpha1,JNK1beta1, JNK2alpha1, JNK2beta1 and JNK3alpha1, which represent the p46 isoforms, and JNK1alpha2, JNK1beta2, JNK2alpha2, JNK2beta2 and JNK3beta2, which represent the p54 isoforms. JNKs coordinate cell responses to stress and influence regulation of cell growth and ransformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in Ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun and other signaling kinases, including MEKK1 and p38.
- UNSPSC12352203