JNK1/2/3 Polyclonal Antibody

Reddot Biotech

JNK1/2/3 Polyclonal Antibody

5

ImmunoHistoChemistry

Research Use Only

Polyclonal

400 ug/ml

Unconjugated

Mapk10

mitogen-activated protein kinase 10

C230008H04Rik; c-Jun N-terminal kinase 3; JNK; JNK3; JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; JNK3B1; JNK3B2; MAP kinase 10; MAP kinase p49 3F12; mitogen-activated protein kinase 10; p493F1; p493F12; p54bSAPK; SAPK(beta); SAPK/Erk/kinase 2; Ser; Serk2; stress-activated protein kinase JNK3

Rabbit

IgG

c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield ten isoforms through alternative mRNA splicing, including JNK1Oe+/-1,JNK1beta1, JNK2Oe+/-1, JNK2beta1 and JNK3Oe+/-1, which represent the p46 isoforms, and JNK1Oe+/-2, JNK1beta2, JNK2Oe+/-2, JNK2beta2 and JNK3beta2, which represent the p54 isoforms. JNKs coordinate cell responses to stress and influence regulation of cell growth and ransformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in Ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun and other signaling kinases, including MEKK1 and p38.

Mouse, Rat

-20°C

12352203