Western Blot analysis of Raw264.7 cell, Mouse brain and heart tissue using JNK2 Polyclonal Antibody at dilution of 1:200
Western Blot analysis of Raw264.7 cell, Mouse brain and heart tissue using JNK2 Polyclonal Antibody at dilution of 1:200
JNK2 Polyclonal Antibody
E-AB-15735
Product group Antibodies
Overview
- SupplierElabscience
- Product NameJNK2 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionResponds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.
- UNSPSC12352203