JNK3 antibody [10E4A4]

GeneTex

JNK3 antibody [10E4A4]

9

WB: 1/500 - 1/2000. ICC/IF: 1/200 - 1/1000. ELISA: 1/10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry

Research Use Only

Monoclonal

10E4A4

Unconjugated

MAPK10

mitogen-activated protein kinase 10

c-Jun N-terminal kinase 3; JNK3; JNK3 alpha protein kinase; JNK3A; MAP kinase 10; MAP kinase p49 3F12; mitogen-activated protein kinase 10; p493F12; p54bSAPK; PRKM10; SAPK1b; stress activated protein kinase beta; stress-activated protein kinase 1b; stress-activated protein kinase JNK3

Mouse

IgG1

Mitogen-activated protein kinase 10

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Human, Mouse

-20°C or -80°C,2°C to 8°C

12352203