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Josamycin Solution, 10 ug/ml in acetone [16846-24-5]

Research Use Only
CDX-J0009
Chemodex
CAS Number16846-24-5
Product group Chemicals
Estimated Purity>98%
Molecular Weight827.99
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Overview

  • Supplier
    Chemodex
  • Product Name
    Josamycin Solution (in acetone) [16846-24-5]
  • Delivery Days Customer
    10
  • ADR Class
    3
  • CAS Number
    16846-24-5
  • Certification
    Research Use Only
  • Concentration
    10 ug/ml
  • Estimated Purity
    >98%
  • Formulation
    Liquid
  • Hazard Information
    Danger,Excepted quantity
  • Molecular Formula
    C42H69NO15
  • Molecular Weight
    827.99
  • Scientific Description
    Chemical. CAS: 16846-24-5. Formula: C42H69NO15. MW: 827.99. Josamycin is a member of the leucomycin family of macrolide antibiotics produced by Streptomyces kitasatoensis. It is an antimicrobial against a wide variety of pathogens. It has activity against Gram-positive an Gram-negative bacteria. The mechanism of action is via inhibition of bacterial protein biosynthesis by binding reversibly to the subunit 50S of the bacterial ribosome, inhibiting peptidyltransferase and ribosomal translocation, thereby inhibiting translocation of peptidyl tRNA. Josamycin may overcome anticancer drug resistance by inhibiting the binding of vinblastine or cyclosporin A to P-glycoprotein (Pgp). It is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics and immunomodulatory effects. - Josamycin is a member of the leucomycin family of macrolide antibiotics produced by Streptomyces kitasatoensis. It is an antimicrobial against a wide variety of pathogens. It has activity against Gram-positive an Gram-negative bacteria. The mechanism of action is via inhibition of bacterial protein biosynthesis by binding reversibly to the subunit 50S of the bacterial ribosome, inhibiting peptidyltransferase and ribosomal translocation, thereby inhibiting translocation of peptidyl tRNA. Josamycin may overcome anticancer drug resistance by inhibiting the binding of vinblastine or cyclosporin A to P-glycoprotein (Pgp). It is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics and immunomodulatory effects.
  • SMILES
    O=C1O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)CC(CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@@H]3O[C@@H](C)[C@H](OC(CC(C)C)=O)[C@](C)(O)C3)[C@@H](N(C)C)[C@H]2O)[C@@H](OC)[C@H](OC(C)=O)C1
  • Storage Instruction
    2°C to 8°C
  • UN Number
    1090
  • UNSPSC
    12352200

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