JR-AB2-011

MedChem Express

JR-AB2-011 [2411853-34-2]

10

2411853-34-2

Research Use Only

99.16

C17H14Cl2FN3OS

398.28

JR-AB2-011 is a selective mTORC2 inhibitor with an IC 50 value of 0.36 microM. JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association ( K i : 0.19 microM) [1] .JR-AB2-011 decreases the phosphorylation level of Akt , decreases MMP2 activity, thereby reducing the ability of tumor cells to migrate and invade. JR-AB2-011 also induces non-apoptotic cell death [2] .

ClC1=C(Cl)C=C(NC(N2/C(SC(C)C2)=N/C3=CC=C(F)C=C3)=O)C=C1

2°C to 8°C

12352200