JTE-607

MedChem Express

JTE-607 [188791-09-5]

10

188791-09-5

Research Use Only

99.27

C25H33Cl4N3O5

597.36

JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including TNF-alpha , IL-1beta , IL-6 , IL-8 and IL-10 , from LPS-stimulated human PBMCs, with IC 50 s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively [1] . Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607 [2] .

CCOC([C@H](CC1=CC=CC=C1)NC(C2=C(C(Cl)=C(C(Cl)=C2)OCCN3CCN(CC3)C)O)=O)=O.Cl.Cl

2°C to 8°C

12352200