Juglone [481-39-0]

TargetMol Chemicals

Juglone [481-39-0]

4

481-39-0

Chemical

Research Use Only

Juglone

98.73%

C10H6O3

174.15

Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 microM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.

3 years

Oc1cccc2C(=O)C=CC(=O)c12

-20°C

12352200