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JW 642

HY-12332
MedChem Express
CAS Number1416133-89-5
DownloadMSDS
Product group Chemicals
Estimated Purity99.90
Molecular Weight462.39
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Overview

  • Supplier
    MedChem Express
  • Product Name
    JW 642 [1416133-89-5]
  • Delivery Days Customer
    10
  • CAS Number
    1416133-89-5
  • Certification
    Research Use Only
  • Estimated Purity
    99.90
  • Molecular Formula
    C21H20F6N2O3
  • Molecular Weight
    462.39
  • Scientific Description
    JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively. IC50 value: 7.6/14/3.7 nM(mouse/rat/human MAGL) [1] Target: MAGL inhibitor JW 642 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s = 31, 14, and 20.6 microM for mouse, rat, and human brain membranes, respectively).
  • SMILES
    O=C(OC(C(F)(F)F)C(F)(F)F)N(CC1)CCN1CC2=CC(OC3=CC=CC=C3)=CC=C2
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200

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