K-975

MedChem Express

K-975 [2563855-03-6]

10

2563855-03-6

Research Use Only

99.64

C16H14ClNO2

287.74

K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma [1] .

C=CC(NC1=CC=C(C)C(OC2=CC=C(Cl)C=C2)=C1)=O

-20°C,2°C to 8°C

12352200