K-Ras ligand-Linker Conjugate 2
HY-129776
Product group Molecular Biology
Overview
- SupplierMedChem Express
- Product NameK-Ras ligand-Linker Conjugate 2
- Delivery Days Customer10
- CertificationResearch Use Only
- Molecular FormulaC45H58N8O7
- Molecular Weight822.99
- Scientific DescriptionK-Ras ligand-Linker Conjugate 2 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 2 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
- SMILESNCCOCCOCCOCCO[C@H]1CN(C)[C@H](COC2=NC3=C(CCN(C4=CC=CC5=C4C=CC=C5)C3)C(N6CCN(C(OCC7=CC=CC=C7)=O)[C@@H](CC#N)C6)=N2)C1
- UNSPSC41115800