K20

MedChem Express

K20

10

Research Use Only

C24H20Cl2F4N4O2

543.34

K20 is a potent and selective KRas G12C inhibitor with an IC50 of 1.16 microM. K20 shows anticancer activity in H358 cells (IC50= 0.78 microM). K20 decreases the levels of phosphorylated Erk and leads to cancer cell apoptosis. K20 suppresses NCI-H358 tumor growth with a TGI of 41% without causing obvious toxicity[1].

C=C(C(N1CCN([C@@H](C1)C)C2=NC=NC3=C(C(C4=CC(Cl)=CC=C4OC)=C(C=C23)Cl)F)=O)C(F)(F)F

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