K284-6111

MedChem Express

K284-6111 [702668-62-0]

9

Research Use Only

99.94

C30H37N3O4S

535.70

K284-6111 is a high-affinity and orally active CHI3L1 inhibitor, and inhibits CHI3L1 expression. K284-6111 inhibits ERK and NF-kappaB pathway. K284-6111 suppresses nuclear translocation of p50 and p65, and phosphorylation of IkappaB. K284-6111 improves memory dysfunction by alleviating amyloidogenesis and neuroinflammation, with the reduction of inflammatory proteins (eg: iNOS, COX-2, GFAP, and Iba-1). K284-6111 reduces atopic-like skin inflammation and inhibits LPS (HY-D1056) -induced liver injury. K284-6111 can be used for the study of Alzheimers diseases and sepsis like hepatic injury[1][2][3][4].

O=C1C2=C(N=C(N1CCC3=CCCCC3)SC(CC)C(NC4=CC=C(CC)C=C4)=O)C=C(OC)C(OC)=C2

-20°C,2°C to 8°C

12131703