Kartogenin (KGN) --- Chondrogenesis Modulator

Bioss

Kartogenin (KGN) --- Chondrogenesis Modulator [4727-31-5]

16

Research Use Only

98.0

Kartogenin (KGN) is a potent small molecule that can promote chondrocyte differentiation of human mesenchymal stem cells/MSCs (EC50 = 100 nM). It was identified by an imaging-based high throughput screening in human MSCs. KGN also shows chondro-protective effects in vitro, and is efficacious in collagenase and surgery induced OA models in mice. MOA studies suggested that KGN binds to filamin A, disrupts its interaction with the transcription factor CBFbeta, and induces chondrogenesis by regulating the CBFbeta-RUNX1 transcriptional program. Kartogenin serves as a very useful tool to study and promote chondrogenesis, and may provide a new strategy of cell-based therapy for treating osteoarthritis.

-20°C

51202000