KB 5666 [131916-69-3]

MedChem Express

KB 5666 [131916-69-3]

9

131916-69-3

Research Use Only

C24H32N4O5

456.53

KB 5666 is a benzoxazine derivative with lipid peroxidation inhibitory activity. KB 5666 showed protective effects against post-ischemic neuronal death. KB 5666 effectively protected CA1 neurons when injected 5 minutes before or immediately after ischemia. KB 5666 also showed a dose-dependent protective effect when injected within 1 hour after ischemia. KB 5666 effectively prevented the significant decrease in microtubule-associated protein 2 immunoreactivity within the dendritic field of CA1 pyramidal cells. KB 5666 prevented the decrease in [3H]PDBu binding activity in different layers of the CA1 region after ischemia. The application of KB 5666 showed the ability to improve the cellular and functional consequences of ischemia[1].

C=CCN1CCN(CC1)C2=NC(OCCCCC)=C3C=CC=CC3=N2.O=C(/C=C/C(O)=O)O

12352200