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ProductsBack/KB130015 [147030-48-6]

KB130015 [147030-48-6]

HY-120026
MedChem Express
CAS Number147030-48-6
Product group Chemicals
Estimated Purity98.28
Molecular Weight548.11
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Overview

  • Supplier
    MedChem Express
  • Product Name
    KB130015 [147030-48-6]
  • Delivery Days Customer
    5
  • CAS Number
    147030-48-6
  • Certification
    Research Use Only
  • Estimated Purity
    98.28
  • Molecular Formula
    C18H14I2O4
  • Molecular Weight
    548.11
  • Scientific Description
    KB130015 (KB015) is an orally active and potent ThRalpha and ThRbeta (thyroid hormone receptor) inhibitor, with IC50 values of 4.5 and 5.1 microM, respectively. KB130015 markedly slows the kinetics of inactivation of Na+ channels. KB130015 activates hERG1 channels (EC50 = 12.2 microM) and large-conductance Ca2+-activated K+ (BKCa) channels formed by hSlo1 (alpha) subunits in HEK 293 cells. KB130015 has antiarrhythmic properties. KB130015 can be used for the study of cardiovascular disease[1][2][3][4].
  • SMILES
    O=C(COC1=C(C=C(C=C1I)CC2=C(OC3=C2C=CC=C3)C)I)O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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