Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA822756LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA822756LA01HU at dilution of 1:100
KCTD6 Antibody
CSB-PA822756LA01HU
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetKCTD6
Overview
- SupplierCusabio
- Product NameKCTD6 Antibody
- Delivery Days Customer20
- ApplicationsELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID200845
- Target nameKCTD6
- Target descriptionpotassium channel tetramerization domain containing 6
- Target synonymsKCASH3, BTB/POZ domain-containing protein KCTD6, potassium channel tetramerisation domain containing 6, potassium channel tetramerization domain-containing protein 6
- HostRabbit
- IsotypeIgG
- Protein IDQ8NC69
- Protein NameBTB/POZ domain-containing protein KCTD6
- Scientific DescriptionProbable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC41116161
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