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Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA822756LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA822756LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA822756LA01HU at dilution of 1:100

KCTD6 Antibody

CSB-PA822756LA01HU
Cusabio
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetKCTD6
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Overview

  • Supplier
    Cusabio
  • Product Name
    KCTD6 Antibody
  • Delivery Days Customer
    20
  • Applications
    ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID200845
  • Target name
    KCTD6
  • Target description
    potassium channel tetramerization domain containing 6
  • Target synonyms
    BTB/POZ domain-containing protein KCTD6; KCASH3; potassium channel tetramerisation domain containing 6; potassium channel tetramerization domain-containing protein 6
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ8NC69
  • Protein Name
    BTB/POZ domain-containing protein KCTD6
  • Scientific Description
    Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887).
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    41116161

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