Bio-Connect

Keap1-Nrf2-IN-8

HY-146578
MedChem Express
Molecular Weight706.76
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Keap1-Nrf2-IN-8 [2769963-54-2]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Molecular Formula
    C35H31FN2O9S2
  • Molecular Weight
    706.76
  • Scientific Description
    Keap1-Nrf2-IN-8 (compound 12d) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor with IC50s of 64.5 nM and 14.2 nM for FP and TR-FRET assays, respectively. Keap1-Nrf2-IN-8 significantly increases the mRNA levels of Nrf2 downstream genes, GSTM3, HMOX2 and NQO1[1].
  • SMILES
    CC1=CC=C(C=C1)S(=O)(N(C2=C3C=CC=CC3=C(C(OCC4=CC=C(C=C4)F)=C2)N(S(=O)(C5=CC=C(C=C5)C)=O)CC(O)=O)CC(O)=O)=O
  • UNSPSC
    12131703