KF26777 (free base) [206129-88-6]

MedChem Express

KF26777 (free base) [206129-88-6]

9

206129-88-6

Research Use Only

C16H16BrN5O

374.24

KF26777 (free base) is a potent and selective adenosine A3 receptor antagonist with an Ki value of 0.2 nM and possesses 9000-, 2350- and 3100-fold selectivity against adenosine A1, A2A and A2B receptors, respectively. KF26777 (free base) potently inhibits the [125I]AB-MECA binding to adenosine A3 receptors. KF26777 (free base) is promising for research of brain ischemia and inflammatory disease including asthma[1].

O=C1N(CCC)C2=C(NC(C3=CC=C(Br)C=C3)=N2)C4=NCCN14

12352200