KG-548 [175205-09-1]

MedChem Express

KG-548 [175205-09-1]

10

175205-09-1

Research Use Only

99.92

C9H4F6N4

282.15

KG-548 is an ARNT/TACC3 disruptor and a HIF-1alpha inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as HIF-beta[1][2].

FC(C1=CC(C(F)(F)F)=CC(C2=NN=NN2)=C1)(F)F

-20°C,2°C to 8°C

12352200