KHK-IN-1 (hydrochloride)

MedChem Express

KHK-IN-1 (hydrochloride) [1303470-48-5]

10

1303470-48-5

Research Use Only

98.47

C21H27ClN8S

459.01

KHK-IN-1 hydrochloride (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 hydrochloride inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM). KHK-IN-1 hydrochloride has potential for the study of diabetes and obesity[1].

[H]Cl.CSC(C=CC=C1)=C1NC2=NC(N3CCNCC3)=NC4=C2N=CN=C4NCC5CC5

-20°C

12352200