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Ki20227

HY-10408
MedChem Express
CAS Number623142-96-1
DownloadMSDS
Product group Chemicals
Estimated Purity99.51
Molecular Weight480.54
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Ki20227 [623142-96-1]
  • Delivery Days Customer
    5
  • CAS Number
    623142-96-1
  • Certification
    Research Use Only
  • Estimated Purity
    99.51
  • Molecular Formula
    C24H24N4O5S
  • Molecular Weight
    480.54
  • Scientific Description
    Ki20227 is an orally active and highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC 50 s of 2 nM, 12 nM, 451 and 217 nM for CSF1R, VEGFR2 (vascular endothelial growth factor receptor-2), c-Kit (stem cell factor receptor) and PDGFRbeta (platelet-derived growth factor receptor beta). Ki20227 suppresses osteoclast differentiation and osteolytic bone destruction [1] .
  • SMILES
    O=C(NC1=CC=C(C=C1OC)OC2=CC=NC3=CC(OC)=C(C=C23)OC)NC(C)C4=NC=CS4
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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