Ki20227

MedChem Express

Ki20227 [623142-96-1]

5

623142-96-1

Research Use Only

99.51

C24H24N4O5S

480.54

Ki20227 is an orally active and highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC 50 s of 2 nM, 12 nM, 451 and 217 nM for CSF1R, VEGFR2 (vascular endothelial growth factor receptor-2), c-Kit (stem cell factor receptor) and PDGFRbeta (platelet-derived growth factor receptor beta). Ki20227 suppresses osteoclast differentiation and osteolytic bone destruction [1] .

O=C(NC1=CC=C(C=C1OC)OC2=CC=NC3=CC(OC)=C(C=C23)OC)NC(C)C4=NC=CS4

-20°C,2°C to 8°C

12352200