KIDINS220 Antibody, FITC conjugated
CSB-PA012306LC01HU
ReactivityHuman
Product group Antibodies
TargetKIDINS220
Overview
- SupplierCusabio
- Product NameKIDINS220 Antibody, FITC conjugated
- Delivery Days Customer20
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateFITC
- Gene ID57498
- Target nameKIDINS220
- Target descriptionkinase D interacting substrate 220
- Target synonymsankyrin repeat-rich membrane-spanning protein; ARMS; kinase D-interacting substrate 220kDa; kinase D-interacting substrate of 220 kDa; SINO; VENARG
- HostRabbit
- IsotypeIgG
- Protein IDQ9ULH0
- Protein NameKinase D-interacting substrate of 220 kDa
- Scientific DescriptionPromotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203