KIM-161

MedChem Express

KIM-161

5

Research Use Only

C27H25N3O3

439.51

KIM-161 is a PIK3CA inhibitor. KIM-161 has significant antiproliferative activity with IC50 values of 1.428 and 1.562 microM against PI3KCA mutant breast cancer MCF7 and T47D cells, respectively. KIM-161 induces apoptosis and cell cycle arrest by inhibiting the PI3K/AKT/mTOR signaling pathway and inducing ROS production. KIM-161 can be used to study breast cancer and its PI3KCA mutant subtypes[1].

O=C(NCC1=CC=CC=C1)CC2=CC=C(N3C(/C(N=C3C)=C/C4=CC=C(OC)C=C4)=O)C=C2

12352200