Kininogen, High Molecular Weight

Athens Research

Kininogen, High Molecular Weight

9

Angiodema, Diabetes, Coagulation, Cancer, Muscular Dystrophy, Joint Disease, In Vitro Diagnostic

Research Use Only

≥95% by SDS-PAGE

Kininogen-1

High Molecular Weight Kininogen (HMWK) is a multifunctional plasma protein primarily synthesized by hepatocytes. As the precursor to bradykinin, HMWK plays a central role in the kallikrein-kinin system, where it is cleaved by plasma kallikrein to release bradykinin, a peptide that mediates vasodilation, increased vascular permeability, and pain signaling. Beyond its role as a bradykinin precursor, HMWK functions as a critical cofactor in the intrinsic pathway of blood coagulation, facilitating the activation of factors XI, XII, and prekallikrein. Additionally, HMWK acts as a major extracellular cysteine proteinase inhibitor, helping to regulate proteaseTyp activity and protect tissues from excessive proteolysis. Dysregulation of HMWK has been implicated in various pathological conditions, including hereditary angioedema, where bradykinin overproduction leads to recurrent swelling episodes. Furthermore, altered kininogen activity is associated with cancer progression, muscular dystrophy, and joint diseases, making HMWK a potential therapeutic target and biomarker in these disorders.

more then 1 year

Source human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

≤ -80°C

12352202