KL1333

MedChem Express

KL1333 [1800405-30-4]

10

1800405-30-4

Research Use Only

99.89

C14H12N2O2

240.26

KL1333, a derivative of beta-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures [1] [2] .

O=C(C1=C2N=C(C(C)C)N1)C(C3=C2C=CC=C3)=O

-20°C,2°C to 8°C

12352200