KLOTHO Antibody (KL2)

QuidelOrtho

KLOTHO Antibody (KL2)

7

The specificity of the monoclonal antibody was established via epitope mapping and a series of immunoassays. The antibody binds the KL2 domain of the Klotho protein.

Other Application

Research Use Only

Monoclonal

IgG1

Klotho, named after one of the Fates in Greek mythology, is a type-I transmembrane protein that is associated with many functions. A novel beta-glucuronidase, Klotho has been associated with phosphate regulation, organ protection, and aging, among others. Though a single gene, it has 3 major isoforms: the transmembrane form, a shed soluble form, and a truncated soluble form. The extracellular portion of the protein consists of two glycosyl hydrolase domains referred to as KL1 and KL2. Upon cleavage at the base of the extracellular domain the protein becomes the shed soluble form, and is an active form that functions as a hormone. This monoclonal antibody was raised against an epitope specific to the KL2 portion of the human Klotho protein.It has been used in the specific applications of immunoprecipitation and western blot. Please contact Quidel Technical Support for details on these or other applications.

-20°C,2°C to 8°C

12352203