KMT2E Antibody

Cusabio

KMT2E Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

KMT2E

lysine methyltransferase 2E (inactive)

HDCMC04P, MLL5, NKp44L, ODLURO, SETD5B, inactive histone-lysine N-methyltransferase 2E, histone-lysine N-methyltransferase 2E, histone-lysine N-methyltransferase MLL5, inactive lysine N-methyltransferase 2E, lysine (K)-specific methyltransferase 2E, myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila), myeloid/lymphoid or mixed-lineage leukemia protein 5

Rabbit

IgG

Inactive histone-lysine N-methyltransferase 2E

Histone methyltransferase that specifically mono- and dimethylates Lys-4 of histone H3 (H3K4me1 and H3K4me2). H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-induced granulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases.

Human, Mouse

-20°C or -80°C

41116161