KMT5A Antibody

Cusabio

KMT5A Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

KMT5A

lysine methyltransferase 5A

PR-Set7, PR/SET07, SET07, SET8, SETD8, N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, H4-K20-HMTase SETD8, H4-K20-specific histone methyltransferase, N-lysine methyltransferase SETD8, PR/SET domain containing protein 8, PR/SET domain-containing protein 07, SET domain containing (lysine methyltransferase) 8, SET domain-containing protein 8, histone-lysine N-methyltransferase KMT5A, histone-lysine N-methyltransferase SETD8, lysine (K)-specific methyltransferase 5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A

Rabbit

IgG

N-lysine methyltransferase KMT5A

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates Lys-20 of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at Lys-382, leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.

Human

-20°C or -80°C

41116161