KNT-127 [1256921-89-7]

MedChem Express

KNT-127 [1256921-89-7]

10

1256921-89-7

Research Use Only

99.60

C24H24N2O2

372.46

KNT-127 is a selective and BBB-penetrant delta-opioid receptor (DOR) agonist (Ki = 0.16 nM). KNT-127 is highly selective to the delta receptor, with Ki values of 0.16, 21.3 and 153 nM for delta, micro and kappa receptors, respectively. KNT-127 acts as a biased ligand that mainly activates cyclic adenosine monophosphate (cAMP) signaling with lower beta-arrestin signaling activation. KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens, and prefrontal cortex. KNT-127 exhibits antidepressant- and anxiolytic-like effects. KNT-127 can be studied in research on neurological diseases[1][2][3][4][5].

O[C@@]12[C@]3(CC4=NC5=CC=CC=C5C=C4C2)C6=CC(O)=CC=C6C[C@H]1N(CC3)C

-20°C,2°C to 8°C

12352200