KPT-185 [1333151-73-7]

MedChem Express

KPT-185 [1333151-73-7]

14

1333151-73-7

Research Use Only

99.04

C16H16F3N3O3

355.31

KPT-185 is an orally bioavailable and selective inhibitor of CRM1 and displays potent antiproliferative properties at submicromolar concentrations (IC50=100-500 nM), induces apoptosis, cell-cycle arrest, and myeloid differentiation in AML cell lines and patient blasts[1].

O=C(OC(C)C)/C=C\N1N=C(C2=CC(C(F)(F)F)=CC(OC)=C2)N=C1

-20°C,2°C to 8°C

12352200