KRAS G12C inhibitor 47 [2253119-24-1]
HY-146537
CAS Number2253119-24-1
Product group Chemicals
Molecular Weight547.02
Overview
- SupplierMedChem Express
- Product NameKRAS G12C inhibitor 47 [2253119-24-1]
- Delivery Days Customer10
- CAS Number2253119-24-1
- CertificationResearch Use Only
- Molecular FormulaC30H28ClFN4O3
- Molecular Weight547.02
- Scientific DescriptionKRAS G12C inhibitor 47 (compound 8-1-1) is a potent KRAS G12C inhibitor with an IC50 of 0.172 microM. KRAS G12C inhibitor 47 shows p-ERK inhibition activities with IC50s of 0.046, 69.8 microM in MIA PaCA-2, A549 cells, respectively. KRAS G12C inhibitor 47 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
- SMILESO=C1N=C(N2CCN(CC2)C(C=C)=O)C3=C(N1C4=C(C(C)C)C=CC=C4)C=C(C5=C(O)C=CC=C5F)C(Cl)=C3
- UNSPSC12131703