KRAS G12C inhibitor 48

MedChem Express

KRAS G12C inhibitor 48 [3033236-94-8]

10

Research Use Only

C36H39ClN8O2

651.20

KRAS G12C inhibitor 48 (compound 6e) is a potent KRAS G12C inhibitor with an IC50 of 639.91 nM. KRAS G12C inhibitor 48 (0-50 microM) shows anti-proliferative activity with IC50s of 0.796, 6.33, 16.14 microM for H358, H23, A549 cells, respectively[1].

N#C/C(C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C(Cl)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)CC1)=O)=C\C7CC7

12131703