KRAS G12C inhibitor 57

MedChem Express

KRAS G12C inhibitor 57 [2821863-70-9]

10

Research Use Only

C35H38FN7O2

607.72

KRAS G12C inhibitor 57 (Compound 50) is a potent, selective, covalent and orally active KRAS G12C inhibitor with an IC50 of 0.21 microM in KRAS G12C/SOS1 binding assay. KRAS G12C inhibitor 57 induces cancer cell apoptosis[1].

N#CC[C@@H]1N(C(C=C)=O)CCN(C2=C3C(N(C)C(C4=C5C(C)=CC=CC5=CC=C4)=C3)=NC(OC[C@@]67CCCN6C[C@H](F)C7)=N2)C1

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