Kras G12D, GST-tag, GppNHp loaded

Aurora Biolabs

Kras G12D, GST-tag, GppNHp loaded

12

Protein

Research Use Only

Kras is a member of the RAS protein family, which are a class of small GTPases involved in cell signaling. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. As an oncogene mutated in several different cancers, the G12D substitution mutation favors the activated, GTP-bound state of the protein.

-80⁰C

12352202