KRas G12R inhibitor 1

MedChem Express

KRas G12R inhibitor 1

10

Research Use Only

98.19

C39H38ClF7N6O9

903.20

KRas G12R inhibitor 1 is a covalent inhibitor targeting the common oncogenic mutant KRas G12R with selectivity for the mutant arginine. KRas G12R inhibitor 1 possesses an alpha,beta-diketoamide and exploits strong nucleophilicity of the mutant cysteine and irreversibly binds in the Switch II region of KRas. KRas G12R inhibitor 1 can be researched for K-Ras (G12R)-driven cancer such as pancreatic ductal adenocarcinoma (PDAC)[1].

CC(C(O)(O)C(N1[C@@H]2CC[C@H]1CN(C3=NC(OCC45CCCN4CCC5)=NC6=C3C=NC(C7=C8C(Cl)=CC=CC8=CC=C7)=C6F)C2)=O)=O.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O

2°C to 8°C

12131703