KRAS inhibitor-12 [2230874-00-5]
HY-146533
CAS Number2230874-00-5
Product group Chemicals
Molecular Weight452.33
Overview
- SupplierMedChem Express
- Product NameKRAS inhibitor-12 [2230874-00-5]
- Delivery Days Customer10
- CAS Number2230874-00-5
- CertificationResearch Use Only
- Molecular FormulaC19H16Cl2FN5OS
- Molecular Weight452.33
- Scientific DescriptionKRAS inhibitor-12 (compound 6-1) is a potent KRAS G12C inhibitor with an IC50 of 0.537 microM. KRAS inhibitor-12 shows p-ERK inhibition activities with IC50s of 1.3, 3.7 microM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-12 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
- SMILESO=C(N1CCN(CC1)C2=C3C=C(Cl)C(C4=C(Cl)C=CC(N)=N4)=C(F)C3=NS2)C=C
- UNSPSC12131703