KRAS inhibitor-17 [2230873-65-9]

MedChem Express

KRAS inhibitor-17 [2230873-65-9]

10

2230873-65-9

Research Use Only

C21H18Cl2FN3O2S

466.36

KRAS inhibitor-17 (compound 3-9) is a potent KRAS G12C inhibitor with an IC50 of 3.37 microM. KRAS inhibitor-17 shows p-ERK inhibition activities with IC50s of 9.25, >33.3 microM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-17 has the potential for the research of pancreatic, colorectal, and lung cancers[1].

C=CC(N1CCN(CC1)C2=C3C=C(C(C4=CC(OC)=CC=C4Cl)=C(C3=NS2)F)Cl)=O

12131703