KRAS inhibitor-18 [2230873-66-0]

MedChem Express

KRAS inhibitor-18 [2230873-66-0]

10

2230873-66-0

Research Use Only

C20H15ClF3N3O2S

453.87

KRAS inhibitor-18 (compound 3-10) is a potent KRAS G12C inhibitor with an IC50 of 4.74 microM. KRAS inhibitor-18 shows p-ERK inhibition activities with IC50s of 66.4, 11.1 microM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-18 has the potential for the research of pancreatic, colorectal, and lung cancers[1].

C=CC(N1CCN(CC1)C2=C3C=C(C(C4=CC(O)=C(C=C4F)F)=C(C3=NS2)F)Cl)=O

12131703