KRAS inhibitor-9

MedChem Express

KRAS inhibitor-9 [300809-71-6]

10

300809-71-6

Research Use Only

99.85

C13H9ClN2S2

292.81

KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 microM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells[1].

NC1=CC=C(SC2=NC3=CC=CC=C3S2)C(Cl)=C1

-20°C,2°C to 8°C

12352200