KRC-00715

Biorbyt

KRC-00715

10

Research Use Only

98.00%

C25H25F3N8O3

542.51

KRC-00715 is an orally effective inhibitor of c-Met, exhibiting high selectivity with an IC50 of 9.0 nM. This compound specifically inhibits the growth of gastric cancer cell lines with high c-Met expression by inducing G1/S phase block, and reduces the activity of downstream signals, including Akt, Erk, and c-Met itself. In the gastric cancer cell line Hs746T, KRC-00715 demonstrates cytotoxicity with an IC50 of 39 nM and selectively inhibits the proliferation of cell lines that overexpress c-Met. Additionally, KRC-00715 decreases tumor size in Hs746T xenograft mouse models.

FC(F)(F)C=1C=C(C=CC1OCCN2CCOCC2)C3=NC4=C(N=NN4CC5OC6=CC=CN=C6NC5)N=C3

-20°C

12352200