KRP-AM1977

Biorbyt

KRP-AM1977 [848416-07-9]

10

848416-07-9

Research Use Only

C21H24F3N3O4

439.4281759

Lascufloxacin, also known as KRP-AM-1977, is a potent antibacterial drug candidate. Lascufloxacin showed a broad spectrum of activity against various clinical isolates. Especially, lascufloxacin showed the most potent activity against gram-positive bacteria among the quinolones tested. Furthermore, lascufloxacin showed incomplete cross-resistance against existing quinolone-resistant strains. Enzymatic analysis indicated that lascufloxacin showed potent inhibitory activity against both wild-type and mutated target enzymes. Lascufloxacin may be useful in treating infections caused by various pathogens, including quinolone-resistant strains.

F[C@@H]1CN(C2=C(C=C3C(C(C(=O)O)=CN(CCF)C3=C2OC)=O)F)C[C@@H]1CNC1CC1

12352200