KSC-34

MedChem Express

KSC-34 [2226201-97-2]

10

2226201-97-2

Research Use Only

98.03

C21H28ClN7O

429.95

KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1) , is also a selective and potent a-site inhibitor of PDIA1 with an IC 50 of 3.5 microM. KSC-34 displays a 30-fold selectivity for a domain over a domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family [1] . KSC-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

O=C(NCCNC1=NC(N(C)CCCCC2=CC=CC=C2)=NC(NCC#C)=N1)CCl

2°C to 8°C

12352200