Western blot analysis of extracts from COS7, 293 and 3T3 cells, using KSR2 antibody.
Western blot analysis of extracts from COS7, 293 and 3T3 cells, using KSR2 antibody.
KSR2 Antibody
CSB-PA581207
ApplicationsImmunoFluorescence, Western Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetKSR2
Overview
- SupplierCusabio
- Product NameKSR2 Antibody
- Delivery Days Customer20
- ApplicationsImmunoFluorescence, Western Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID283455
- Target nameKSR2
- Target descriptionkinase suppressor of ras 2
- Target synonymskinase suppressor of Ras 2
- HostRabbit
- IsotypeIgG
- Protein IDQ6VAB6
- Protein NameKinase suppressor of Ras 2
- Scientific DescriptionLocation-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Ota T., Nat. Genet. 36:40-45(2004). Scherer S.E., Nature 440:346-351(2006). Channavajhala P.L., J. Biol. Chem. 278:47089-47097(2003).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203