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KT 5720

Research Use Only
M7877
AbMole BioScience
CAS Number108068-98-0
Product group Chemicals
Molecular Weight537.61
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    KT 5720
  • Delivery Days Customer
    9
  • CAS Number
    108068-98-0
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Molecular Formula
    C32H31N3O5
  • Molecular Weight
    537.61
  • Scientific Description
    KT 5720 is a specific, reversible, ATP-competitive, cell-permeable protein kinase A (PKA) inhibitor with an IC50 value of 3.3 uM, which effectively reverses MDR1-mediated multidrug resistance and reduces excitability of dorsal root ganglion (DRG) neurons by attenuating the activity of hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels and decreasing the intracellular Ca2+ concentration. ) neurons by reducing hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channel activity and intracellular Ca2+ concentration. It can be used in the study of hematologic malignancies and diseases associated with HCN and DRG neurons.
  • UNSPSC
    12352200