KT109 [1402612-55-8]

MedChem Express

KT109 [1402612-55-8]

10

1402612-55-8

Research Use Only

99.86

C27H26N4O

422.52

KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-beta (DAGLbeta) with an IC50 of 42 nM. KT109 has ~60-fold selectivity for DAGLbeta over DAGLalpha. KT109 shows inhibitory activity against PLA2G7 (IC50=1 microM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-Arachidonoylglycerol (HY-W011051), Arachidonic acid (HY-109590) and eicosanoids in mouse peritoneal macrophages[1].

O=C(N1N=NC(C2=CC=C(C3=CC=CC=C3)C=C2)=C1)N4CCCCC4CC5=CC=CC=C5

-20°C,2°C to 8°C

12352200