KY19382

MedChem Express

KY19382 [2226664-93-1]

9

2226664-93-1

Research Use Only

98.0

C17H11Cl2N3O2

360.19

KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3beta, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/beta-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3beta activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases[1][2].

O=C1NC2=C(C=C(Cl)C(Cl)=C2)/C1=C3NC4=C(C=CC=C4)C/3=N/OC

-20°C,2°C to 8°C

12352200